| Spanky | Man | American Names |
| Sparkle | Woman | American Names |
| Sparks | Unisex | English Names |
| Sparrow | Unisex | English Names |
| Sparta | Unisex | Greek Names |
| Spence | Man | English Names |
| Spencer | Unisex | English Names |
| Speranza | Woman | Italian Names |
| Spicer | Man | American Names |
| Spike | Man | American Names |
| Spirit | Unisex | English Names |
| Spiro | Man | Greek Names |
| Spock | Man | Scandinavian Names |
| Sprague | Man | English Names |
| Sprig | Unisex | American Names |
| Spring | Unisex | English Names |
| Springer | Unisex | English Names |
| Spurgeon | Unisex | Scandinavian Names |
| Spyridon | Man | Greek Names |
| Squire | Unisex | English Names |